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The most objective marker is laboratory evidence of suboptimal glycemic control, including hemoglobin A1c values above individualized targets or persistent hyperglycemia on self-monitoring blood glucose data

Weight loss should be consistent and exceed your semaglutide trajectory

Patients should check their blood glucose during symptomatic episodes, especially if taking insulin or sulfonylureas alongside tirzepatide, as hypoglycemia can cause similar symptoms

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You must take the pill immediately upon waking on an empty stomach with no more than 4 ounces of water

Two weeks after stopping: Drug levels are much lower, but some people still notice reduced hunger or mild lingering effects